本所曾对7,901例患者在1年内的服药情况进行考核,发现不规则服药者以在工作的病人,单服异菸肼者最为严重(占全部单用一药病人的23.6％)。患者不规则服药原因,除由于药物反应或对药物疗效失却信心之外,大多数是因为工作时携带不便,遗忘服用所致。为了探讨服用次数的改变对疗效的影响,我们自1962年7月起选择工厂初治肺结核患者300例分别进行异菸肼每日300毫克1次口 We reviewed 7,901 patients taking medication within one year and found that those who took medication irregularly were the most serious (23.6% of all single-agent patients) with single-dose isoniazid. Patients with irregular medication reasons, in addition to the lack of confidence because of drug reactions or the efficacy of the drug, the majority is due to inconvenience during work, forgotten to take due. In order to explore the impact of changes in the number of taken on the efficacy, we have selected 300 patients with newly diagnosed tuberculosis in our factory since July 1962 to administer 300 mg once daily of isoniazid