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目的:观察胆囊癌手术以后化疗期间配合口服中药的调理作用。方法:将所有就诊于医院外科的胆囊癌患者共46例,随机分为治疗组与对照组两组,每组各23例,根据患者本身的身体状况、癌变分期、癌肿范围等情况选择不同的手术方案,手术以后对症接受基本的营养支持治疗。对照组于术后4~6周开始化学疗法治疗,进行2个化疗周期;治疗组于化疗前1周至化疗后1周期间服用自拟中药抗癌利胆汤,每日1剂,分早晚2次口服,每次100 mL,疗程结束后观察疗效。结果:疗程结束后治疗组与对照组中医证候疗效有效率分别为60.8%、30.4%,两组相比,有显著性差异(P<0.05)。治疗后两组中医症状积分分别为(8.2±2.3)、(16.3±5.6),两组相比,治疗组明显优于对照组,有显著性差异(P<0.05)。疗程结束后,治疗组的Karnofsky评分及ZPS评分均高于对照组,两组相比,有统计学差异(P<0.05)。在改善血细胞计数及免疫T细胞亚群方面,治疗组可以明显提高白细胞、血小板数量以及CD4、CD8细胞的数量,两组相比,有显著性差异(P<0.05)。在两组治疗后主要不良反应比较中,治疗组的不良反应发生率明显低于对照组,与对照组相比较有显著性差异(P<0.05)。结论:胆囊癌术后化疗时配合中药治疗口服,可以减少胆囊癌患者术后的并发症改善其生存质量,还能提高人体免疫机能,提高人体抗病力,效果明显优于对照组,值得临床推广使用。
Objective: To observe the role of oral Chinese medicine during chemotherapy after gallbladder cancer surgery. Methods: A total of 46 patients with gallbladder cancer who were hospitalized in the hospital were randomly divided into treatment group and control group, with 23 patients in each group. Patients were selected according to the patient's physical condition, cancer stage, Of the surgical options, symptomatic surgery after surgery to accept basic nutritional support. The control group started chemotherapy treatment 4 to 6 weeks after the operation and performed 2 cycles of chemotherapy. The treatment group took self-made anticancer and anti-cancer gallbladder soup 1 week before chemotherapy and 1 week after chemotherapy, Oral administration, each time 100 mL, observe the effect after the end of treatment. Results: After treatment, the effective rates of TCM syndromes in treatment group and control group were 60.8% and 30.4% respectively, there was significant difference between the two groups (P <0.05). The score of TCM symptom in the two groups after treatment was (8.2 ± 2.3) and (16.3 ± 5.6) respectively, which was significantly higher in the treatment group than in the control group (P <0.05). After treatment, Karnofsky score and ZPS score in the treatment group were higher than those in the control group, there was a significant difference between the two groups (P <0.05). The treatment group can significantly improve the number of white blood cells, platelets and the number of CD4, CD8 cells in improving blood cell count and immune T cell subsets, there was significant difference between the two groups (P <0.05). In the two groups after treatment of major adverse reactions, the treatment group adverse reaction rate was significantly lower than the control group, compared with the control group was significantly different (P <0.05). Conclusions: Postoperative chemotherapy of gallbladder cancer with oral administration of traditional Chinese medicine can reduce the postoperative complications of gallbladder cancer patients to improve their quality of life, but also improve human immune function, improve human body resistance to disease, the effect was significantly better than the control group, it is worth clinical Promote use.