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目的探讨非酒精性脂肪肝(NAFLD)血清Chemerin、肿瘤坏死因子-α(TNF-α)和白介素6(IL-6)变化及关系。方法收集NAFLD组患者60例(包括单纯性脂肪肝39例,非酒精性脂肪性肝炎21例)和正常对照组29例。采用ELISA法测定NAFLD组和健康对照组Chemerin、肿瘤坏死因子-α(TNF-α)和IL-6水平变化。结果 NAFLD组的血清Chemerin、TNF-α和IL-6水平明显高于对照组(P<0.01);血清Chemerin与TNF-α、IL-6呈正相关(r=0.734,P<0.01;r=0.733,P<0.01)。结论 Chemerin、TNF-α及IL-6的异常表达可能与NAFLD的发生发展有关。
Objective To investigate the relationship between serum Chemerin, tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in non-alcoholic fatty liver disease (NAFLD) Methods Sixty patients (including 39 cases of simple fatty liver and 21 cases of non-alcoholic steatohepatitis) in NAFLD group and 29 cases of normal control group were collected. The levels of Chemerin, tumor necrosis factor-α (TNF-α) and IL-6 in NAFLD group and healthy control group were measured by ELISA. Results The levels of serum Chemerin, TNF-α and IL-6 in NAFLD group were significantly higher than those in control group (P <0.01). There was a positive correlation between serum Chemerin and TNF-α and IL-6 (r = 0.734, , P <0.01). Conclusion The abnormal expression of Chemerin, TNF-α and IL-6 may be related to the occurrence and development of NAFLD.