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目的:分析血液灌流联合持续床边血液滤过在有机磷中毒抢救中的临床效果。方法:选择在本院接受住院治疗的有机磷中毒的患者作为研究对象,随机分为接受常规内科治疗的对照组患者及接受血液灌流联合持续床边血液滤过的观察组患者,比较接受治疗前后两组患者的基本住院情况、炎性细胞因子水平、并发症发生情况。结果:①观察组患者接受血液灌流联合持续床边血液滤过治疗后的各项炎性细胞因子水平均明显低于对照组患者(P<0.05);②观察组患者接受治疗后的昏迷苏醒时间、机械通气时间、ChE恢复时间、总住院时间均显著低于对照组患者(P<0.05);③观察组患者接受治疗后的各项并发症发生率均明显低于对照组患者(P<0.05)。结论:血液灌流联合持续床边血液滤过可以有效改善有机磷中毒患者的病情、降低炎症水平,减少并发症的发生,具有积极的临床意义。
Objective: To analyze the clinical effect of hemoperfusion combined with continuous bed hemofiltration in the rescue of organophosphate poisoning. Methods: Patients in our hospital who were hospitalized for organophosphate poisoning were randomly divided into control group receiving routine medical treatment and observation group receiving hemoperfusion combined with continuous bedside hemofiltration. Patients were compared before and after treatment The two groups of patients in the basic hospitalization, levels of inflammatory cytokines, complications occurred. Results: ①The levels of inflammatory cytokines in the observation group were significantly lower than those in the control group after hemoperfusion combined with continuous bed hemofiltration (P <0.05); ② The coma recovery time , Mechanical ventilation time, recovery time of ChE and total length of hospital stay were significantly lower than those in the control group (P <0.05) .③The morbidity of complication in the observation group was significantly lower than that in the control group (P <0.05) ). Conclusion: Hemoperfusion combined with continuous bedside hemofiltration can effectively improve the condition of patients with organophosphate poisoning, reduce the level of inflammation and reduce the occurrence of complications, and has a positive clinical significance.