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过去30年中肿瘤化疗的进步,使得睾丸癌、淋巴瘤、白血病和前列腺癌等肿瘤的生存率和治愈率有了突破性的提高。但是许多化疗药物,如盐酸丙卡巴肼、环磷酰胺和烷基化药物等,有生殖腺毒性,会损害生育能力。骨肉瘤和尤文肉瘤高发于未成年人和青年人,30年前生存率仅为20%,现在则达到了70%。尽管化疗提高了病人的远期生存率,并为保肢手术提供了有利条件,但同时会出现生殖腺毒性,并损害远期生育能力。该文作者侧重探索骨肉瘤化疗是否会影响生育人群的受孕;骨肉瘤化疗病人中打算生育的比率以及受孕的成功率;受孕病人中成功妊娠的比率;化疗是否
The advances in chemotherapy of tumors over the past 30 years have led to a dramatic increase in the survival and cure rates of tumors such as testicular cancer, lymphoma, leukemia and prostate cancer. However, many chemotherapeutic drugs, such as procarbazine hydrochloride, cyclophosphamide and alkylating drugs, have gonadal toxicity and can impair fertility. Osteosarcomas and Ewing’s sarcomas are found in minors and young adults, with a survival rate of only 20% 30 years ago and now 70%. Although chemotherapy increases the long-term survival of patients and provides favorable conditions for limb salvage surgery, gonadal toxicity and impaired long-term fertility may occur. The authors focus on exploring whether osteosarcoma chemotherapy affects the fertility population’s fertility; rates of intend-to-reproductive in osteosarcoma chemotherapy patients and success rates of conceptions; the rate of successful pregnancies in conception patients; whether chemotherapy