蛋白激酶(mammalian sterile20-like kinase,Mst)是体内普遍表达的一种丝/苏氨酸蛋白激酶,属于人丝/苏氨酸激酶的哺乳动物STE20样激酶。首先在酵母中被鉴定,随后发现其参与大量不同的细胞功能的调节。在果蝇模型中,经证实Hippo-Lats-Yorkie信号通路参与细胞过度生长以及肿瘤的发生。在哺乳动物中与Hippo类似的是Mst1。通过Hippo信号通路,Mst1 Mammalian sterile 20-like kinase (Mst) is a silk / threonine protein kinase that is commonly expressed in the body and belongs to mammalian STE20-like kinase of human silk / threonine kinase. It was first identified in yeast and subsequently found to be involved in the regulation of a large number of different cellular functions. In the Drosophila model, the Hippo-Lats-Yorkie signaling pathway has been shown to be involved in cell overgrowth and tumorigenesis. Similar to Hippo in mammals is Mst1. Through the Hippo signal path, Mst1