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低氧性肺动脉高压是缺氧环境下一种常见的临床症状,其主要特征为肺血管收缩反应增强和肺血管结构重构,是许多高原病的重要发病机制之一。肺血管内皮细胞产生的一氧化氮作为一种气体信号分子,具有舒张血管平滑肌,减少肺血管阻力作用。目前研究认为一氧化氮信号通路与低氧性肺动脉高压的发生、发展密切相关,而寻找新型一氧化氮途径靶点药物也已经成为治疗此类疾病的研究热点。本文对低氧性肺动脉高压与一氧化氮信号途径关系的最新研究进展做一概述。
Hypoxic pulmonary hypertension is a common clinical symptom in hypoxic environment. Its main characteristic is the enhancement of pulmonary vasoconstriction and remodeling of pulmonary vascular structure, which is one of the most important pathogenesy of altitude sickness. Nitric oxide produced by pulmonary vascular endothelial cells acts as a gas signaling molecule and has the effects of relaxing vascular smooth muscle and reducing pulmonary vascular resistance. The current study suggests that nitric oxide signaling pathway is closely related to the occurrence and development of hypoxic pulmonary hypertension, and finding a new target of nitric oxide pathway drugs has also become a research hotspot in the treatment of such diseases. This review summarizes recent advances in the relationship between hypoxic pulmonary hypertension and nitric oxide signaling.