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目的:探讨妊娠高危因素与早孕期筛查母血清标志物的关系,并分析不良妊娠结局与以上指标变化的关系。方法:采用时间分辨免疫荧光检测技术,对孕10~13周的252例孕妇,进行早孕期筛查妊娠相关血浆蛋白A(PAPP-A)、游离β人绒毛促性腺激素(freeβ-HCG)检测,将孕妇分为高龄组、高危组、对照组3组,分别比较妊娠结局。结果:PAPP-A、Freeβ-HCG的中位倍数值(MOM)高危组分别为0.88和0.91,高龄组为1.22和1.17。不良妊娠结局组的中位数MOM值呈现低值,PAPP-A与对照组的MOM值差异有统计学意义。结论:PAPP-A的检测对监测自发性流产、胎儿畸形等不良妊娠结局具有一定的临床价值。
Objective: To investigate the relationship between risk factors of pregnancy and maternal serum markers in early pregnancy, and to analyze the relationship between adverse pregnancy outcomes and the above indexes. Methods: A total of 252 pregnancies from 10 to 13 weeks pregnant were enrolled in this study. Pregnancy-associated plasma protein A (PAPP-A) and free β-HCG were detected by time-resolved immunofluorescence assay , Pregnant women were divided into advanced age group, high-risk group, control group 3 groups, compared pregnancy outcomes. Results: The median multiple value (MOM) of PAPP-A and Freeβ-HCG were 0.88 and 0.91 in high risk group and 1.22 and 1.17 in senior group. The median MOM value of adverse pregnancy outcome group showed low values, and the differences of MOM values between PAPP-A and control group were statistically significant. Conclusion: The detection of PAPP-A has certain clinical value in monitoring of adverse pregnancy outcomes such as spontaneous abortion and fetal malformation.