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用病例一对照研究方法,探讨肝癌高发区广西隆安县丙型肝炎病毒(HCV)与原发性肝癌(PLC)的关系。结果显示,丙肝病毒感染标志抗-HCV阳性率在肝癌病例组显著高于对照组,分别为11.5％(10/87)和1.3％(1/80)(P<0.01)。抗-HCV阳性者的肝癌患者均检出HBsAg和抗-HBc阳性,占HBsAg阳性肝癌病例的13.7％(10/72)。抗-HCV阳性的HBsAg携带者发生肝癌的相对危险性为145.3,远高于抗-HcV阴性的HBsAg携带者发生肝癌相对危险性(25.6)。10例抗-HCV阳性的肝癌患者均无受血史,9例(90％)无手术史。提示肝癌高发区肝癌发病与丙肝病毒感染有关。丙肝病毒(HCV)在肝癌发病中与乙肝病毒协同作用,使肝癌发病的相对危险性显著增加。
A case-control study was conducted to investigate the relationship between Hepatitis C virus (HCV) and primary hepatocellular carcinoma (PLC) in Longan County, Guangxi. The results showed that the positive rate of anti-HCV positive for HCV infection was significantly higher in HCC cases than in controls (11.5% (10/87) and 1.3% (1/80), respectively) (P <0.01). HBsAg and anti-HBc positive were detected in patients with anti-HCV positive liver cancer, accounting for 13.7% (10/72) of HBsAg positive liver cancer cases. The relative risk of HCC in anti-HCV positive HBsAg carriers was 145.3, much higher than the relative risk of HCC in anti-HCV negative HBsAg carriers (25.6). None of the 10 patients with anti-HCV positive HCC had blood history, and 9 patients (90%) had no history of surgery. Tip high incidence of liver cancer incidence of liver cancer and hepatitis C virus infection. Hepatitis C virus (HCV) has a synergistic effect with hepatitis B virus in the pathogenesis of liver cancer, and the relative risk of liver cancer is significantly increased.