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目的探讨MP感染对哮喘急性发作患儿临床特点及免疫功能的影响。方法将64例支气管哮喘急性发作患儿分为MP感染组27例与非MP感染组37例,比较分析MP感染组与非MP感染组患儿的临床特点、肺功能情况及血清中IL-4、IFN-γ、IgE的水平。结果 MP感染组临床表现更为复杂、有更明显的肺外表现;存在明显的限制性通气功能障碍;血清IL-4、IFN-γ、IgE水平明显升高,而INF-γ与IL4比值明显降低,差异均有统计学意义(P<0.05)。结论 MP感染诱发的哮喘急性发作患儿临床表现更为复杂;MP感染参与哮喘患儿免疫机制。
Objective To investigate the effect of MP infection on clinical features and immune function in children with acute asthma attack. Methods Sixty-four children with acute exacerbation of bronchial asthma were divided into two groups: 27 in MP group and 37 in non-MP group. The clinical features, lung function and IL-4 level in serum of MP-infected and non-MP- , IFN-γ, IgE levels. Results The clinical manifestations of MP infection were more complicated with more obvious extrapulmonary manifestations. There were obvious restrictive ventilation dysfunction. Serum levels of IL-4, IFN-γ and IgE were significantly increased, while the ratio of INF-γ and IL4 was significantly higher Reduce, the difference was statistically significant (P <0.05). Conclusions The clinical manifestations of children with acute asthma attack induced by MP infection are more complicated. MP infection is involved in the immune mechanism of asthma in children.