与其它器官和组织相比,骨骼和关节的抗感染能力较差,而且它们一旦被感染,则难以治疗。同时它们可能留下后遗症,如骨骼挛缩或变形,关节强直等。因此,在骨和关节的外科手术期间,预防感染是非常重要的。各种抗生素广泛用于手术后感染的预防,但其最佳剂量尚不易确立。所有的抗生素都能引起某些副作用,而且症状可能是相当严重的,因此,避免大量滥用抗生素十分必要。与此相反,如果抗生素的剂量太低,感染的危险性将会增大。为了确立抗生素的最低必要剂量和给药间隔,必需了解抗生素在靶组织内达到的浓 Bones and joints are less resistant to infection than other organs and tissues, and they are difficult to treat once they are infected. At the same time they may leave sequelae, such as contracture or deformation of the bones, ankylosis and so on. Therefore, prevention of infection is very important during the surgery of the bones and joints. Various antibiotics are widely used in the prevention of postoperative infections, but the optimal dose is not easy to establish. All antibiotics can cause certain side effects, and the symptoms can be quite severe, so it is imperative to avoid the abuse of antibiotics in large quantities. In contrast, if the antibiotic dose is too low, the risk of infection will increase. In order to establish the minimum necessary dose of antibiotics and dosing interval, it is necessary to know the concentration of antibiotics that is reached in the target tissue