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尽管类风湿关节炎(rheumatoid arthritis,RA)的病因及发病机制尚未完全明确,但研究证实:RA滑膜细胞及滑膜组织中浸润的单核/巨噬细胞、淋巴细胞等产生大量的细胞因子,这些细胞因子通过作用于多种细胞并相互调节,形成一个复杂的网络,促进了RA的发生和发展。而其中一些炎性细胞因子如肿瘤坏死因子-α、白细胞介素-1、白细胞介素-15、白细胞介素-18、白细胞介素-6、白细胞介素-12和白细胞介素-17等在RA滑膜病变中起核心作用。研究这些炎性细胞因子的生物学功能、在RA发病过程中的作用将有助于进一步明确RA的发病机制,并为研制治疗RA新药提供理论依据。
Although the etiology and pathogenesis of rheumatoid arthritis (RA) have not yet been completely elucidated, studies have shown that infiltrating monocytes / macrophages, lymphocytes and the like in RA synovial cells and synovial tissues produce large amounts of cytokines These cytokines act on many kinds of cells and regulate each other to form a complex network, which promotes the occurrence and development of RA. Some of these inflammatory cytokines such as TNF-alpha, IL-1, IL-15, IL-18, IL-6, IL- Plays a central role in RA synovial lesions. Studying the biological function of these inflammatory cytokines in the pathogenesis of RA will help to further clarify the pathogenesis of RA and provide a theoretical basis for the development of new drugs for RA.