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合成了一种新的含有ＳＮＮ结构的三齿配体Ｎ＇－（２巯基－２－甲基异丙基）－Ｎ，Ｎ－二乙基乙二胺（ＭＤＥＤＡ）。用９９ｍＴｃ－葡庚糖配体交换法与不同的单齿硫酸制备了４种９９ｍＴｃ的“３＋１”混配配合物，标记率均大于９０％。对标记率的影响因素如ｐＨ、温度等作了探讨，并作了小鼠体内的分布实验和家兔的ＳＰＥＣＴ显像。实验表明这些配合物在血中的摄取和滞留远远超过了其他脏器，其中以配合物５ｃ的血滞留最好，有望达到血池显像剂的要求。
A novel tridentate ligand N ’- (2-mercapto-2-methylisopropyl) -N, N-diethylethylenediamine (MDEDA) with SNN structure was synthesized. Four kinds of 99mTc “3 + 1” mixed complexes were prepared by 99mTc-glucanotetracol exchange method with different monodentate sulfuric acid. The labeling rates were all greater than 90%. Factors affecting the labeling rate such as pH and temperature were discussed, and the distribution experiment in mice and SPECT imaging in rabbits were made. Experiments show that these complexes in the blood uptake and retention far more than other organs, of which the best 5c blood retention, is expected to reach the blood pool imaging agent requirements.