目的:观察替硝唑与盐酸米诺环素软膏联合治疗牙周病的疗效。方法:将东莞市塘厦医院口腔科于2015年2月至2016年2月收治的100例牙周病患者分为对照组与观察组各50例。对照组给予甲硝唑治疗,观察组采用替硝唑与盐酸米诺环素软膏联合治疗。评估两组疗效并对比不良反应。结果:观察组患者治疗总有效率94.0%,较对照组78.0%明显更高,差异具有统计学意义(P<0.05)。观察组患者的不良反应发生率4.0%,明显低于对照组的20.0%,差异具有统计学意义(P<0.05)。结论:替硝唑与盐酸米诺环素软膏联合用药治疗牙周病效果确切,用药安全性较高。 Objective: To observe the effect of tinidazole and minocycline hydrochloride ointment in the treatment of periodontal disease. Methods: One hundred patients with periodontal disease who were admitted to Tangxia Hospital of Dongguan from February 2015 to February 2016 were divided into control group and observation group with 50 cases each. The control group was treated with metronidazole, the observation group was treated with tinidazole and minocycline hydrochloride ointment. The two groups were evaluated for efficacy and adverse reactions. Results: The total effective rate of the observation group was 94.0%, which was significantly higher than 78.0% of the control group, the difference was statistically significant (P <0.05). The incidence of adverse reactions in the observation group was 4.0%, which was significantly lower than that in the control group (20.0%), the difference was statistically significant (P <0.05). Conclusion: Tinidazole and minocycline hydrochloride ointment combined treatment of periodontal disease exact effect, medication safety.