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目的观察膀胱内灌注透明质酸钠治疗非细菌性膀胱炎的疗效及安全性。方法对28例非细菌性膀胱炎患者行膀胱内灌注透明质酸钠溶液(50 mL/40 mg),每周灌注1次,连续4周;后改为两周1次,连续4周;最后每月灌注1次,连续2月。两周随访1次,随访至第16周,根据患者主观感受填写疼痛视觉模拟量表VAS、LUTS症状评分、记录排尿日记,观察并分析变化以评价其疗效和安全性。结果 28例患者均完成灌注疗程及随访,第16周时VAS评分由治疗前6.86±1.74下降至2.71±0.90(P<0.001),LUTS评分由治疗前41.07±11.96下降至23.25±6.07(P<0.001);膀胱容量均值由治疗前(106.71±22.65)mL上升至(163.93±32.00)mL(P<0.001)。结论膀胱内灌注透明质酸钠治疗非细菌性膀胱炎的短期疗效及安全性值得肯定,能明显缓解症状,从而提高生活质量。
Objective To observe the efficacy and safety of intravesical instillation of sodium hyaluronate for non-bacterial cystitis. Methods 28 cases of non-bacterial cystitis patients were intravesical instillation of sodium hyaluronate solution (50 mL / 40 mg) once a week for 4 weeks, then 2 weeks for 4 weeks, and finally Perfusion once a month for two consecutive months. Two weeks follow-up was followed up to the 16th week. VAS and LUTS symptom scores were recorded according to subjective feelings of patients. Vomit diary was recorded. Variation was observed and analyzed to evaluate its efficacy and safety. Results 28 patients completed perfusion and follow-up. The VAS score decreased from 6.86 ± 1.74 to 2.71 ± 0.90 (P <0.001) before treatment and LTSS decreased from 41.07 ± 11.96 to 23.25 ± 6.07 (P < 0.001). The average bladder volume increased from (106.71 ± 22.65) mL to (163.93 ± 32.00) mL before treatment (P <0.001). Conclusion The short-term curative effect and safety of intravesical instillation of sodium hyaluronate for the treatment of non-bacterial cystitis are worthy of affirmation, which can obviously relieve the symptoms and improve the quality of life.