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果糖-甘露醇试验测定了非活动性克隆病患者的肠通透性。 经临床、放射学、内镜与组织学检查确诊的非活动性克隆病72例为研究对象,其克隆病活动指数(CDAI)<150,且至少已半年,也未接受维持治疗。对照组为年龄配对的志愿者30例。 受试者禁食一夜,于饮试验液前收集一次小便,以排除有内源性甘露醇产生的可能。试验液为甘露醇5g、乳果糖10g,葡萄糖22g加水至150ml(渗透压≈1300mOsmol/L)。饮试验液后5h收集的小便(加防腐剂叠氮化钠)贮存于-80℃。试验期间禁食,但前2h可饮水。
The fructose-mannitol test measures bowel permeability in patients with inactive clones. 72 cases of non-active Crohn’s disease diagnosed by clinical, radiological, endoscopic and histological examination were studied. Their CDAI <150 and at least half a year did not receive maintenance therapy. The control group consisted of 30 paired volunteers. Subjects were fasted overnight and urine was collected prior to drinking test fluid to exclude the possibility of endogenous mannitol production. The test solution is mannitol 5g, lactulose 10g, glucose 22g water to 150ml (osmotic pressure ≈ 1300mOsmol / L). Urine collected 5h after drinking test solution (plus preservative sodium azide) stored at -80 ℃. Fasting during the test, but before the 2h drinking water.