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β-内酰胺类抗生素的作用机制是抑制与细菌细胞壁合成有关的多种酶,这些酶在细胞膜上能催化粘肽多聚物之间的交链反应。交链作用增加细胞壁的坚固性,对细胞来说是很重要的。能同β-内酰胺类偶合并把它束缚在其活性位置上的某些酶称为青霉素结合蛋白(PBP_5)。敏感性葡萄球菌和甲氧西林耐药性葡萄球菌的根本区别在于它们具有不同的 PBP_s。
The mechanism of action of β-lactam antibiotics is to inhibit the various enzymes involved in the bacterial cell wall synthesis, which catalyze the cross-linking reaction between mucinopeptide polymers on the cell membrane. Cross-linking increases the robustness of the cell wall and is important for the cell. Some of the enzymes that can be coupled to a beta-lactam and bind it to its active site are called penicillin-binding proteins (PBP-5). The fundamental difference between susceptible and methicillin-resistant staphylococci is that they have different PBP_s.