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目的:研究西他沙星对小鼠动物模型金黄色葡萄球菌(Staphylococcus aureus,SA)的抑制作用。方法:采用体外检测不同浓度西他沙星对SA 8325-4和SA 04018的杀灭作用,同时采用腹腔注射SA建立小鼠腹膜炎感染的动物模型,并在此基础上,通过腹腔给药的方式,检测不同剂量西他沙星给药后小鼠死亡率的变化。结果:西他沙星能够有效抑制SA生长;给予小鼠腹腔注射SA后,能够诱发小鼠急性腹膜炎,24 h后小鼠死亡率达87.5%,给予不同剂量的西他沙星可以有效降低小鼠死亡率。结论:西他沙星可以有效地抑制SA诱发的感染,对小鼠具有良好的保护作用。
Objective: To study the inhibitory effect of xanthoxacin on the mouse model of Staphylococcus aureus (SA). Methods: The killing effect of different concentrations of sitafloxacin on SA 8325-4 and SA 04018 was detected in vitro. At the same time, the animal model of peritonitis in mice was established by intraperitoneal injection of SA, and on the basis of which, , The detection of different doses of citalopus administration of mice after the death rate changes. Results: Sitafloxacin can effectively inhibit the growth of SA. After intraperitoneal injection of SA, mice can induce acute peritonitis, the mortality rate of mice reached 87.5% after 24 h, and different doses of Sitafloxacin can effectively reduce the small Rat mortality. Conclusion: Sitafloxacin can effectively inhibit SA-induced infection and has good protective effect on mice.