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世界人口的高增长率和非意愿妊娠的高发生率一直影响着社会经济发展和人类身体健康。传统的避孕方法(输精管结扎、激素类避孕药以及避孕套等)都存在一定的局限性[1]。有研究发现,输精管结扎术后中远期会出现附睾淤积增厚的超声表现[2]。因此,寻找一种安全、方便、有效、可逆的避孕措施对控制人口增长和避免非意愿性妊娠具有十分重要的意义。免疫性避孕的基本原理是选择与生殖过程相关的关键抗原,删除其抑制性表位、自身抗原交叉反应表位等一些非优势抗原表位,添加促使机体发生免疫应答
The high rates of world population growth and the high incidence of unwanted pregnancies have always affected socio-economic development and human health. The traditional methods of contraception (vasectomy, hormonal contraceptives and condoms, etc.) have some limitations [1]. Some studies have found that vasectomy in the long run there will be epididymal deposition thickening of the ultrasound findings [2]. Therefore, looking for a safe, convenient, effective and reversible contraceptive measures is very important to control population growth and avoid unwanted pregnancy. The basic principle of immune contraception is to choose the key antigen associated with the reproductive process, delete its inhibitory epitopes, autoantigen cross-reactivity epitopes and some non-dominant epitopes, add to promote the body to produce immune response