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为探讨P53基因突变与膀胱癌病理分级和临床分期的关系，应用银染PCR-SSCP技术分析46例膀胱癌石蜡标本中P53基因突变情况，结果显示膀胱癌中P53基因突变率为30．4％，分化不良的Ⅲ级膀胱癌P53基因突变率显著高于Ⅰ、Ⅱ级分化较好者。发生浸润和转移的T3－4期膀胱癌P53基因突变率显著高于Tia－T1期表浅性膀胱癌。提示：P53基因突变是膀胱癌恶性程度的生物学标志之一，可用来评估患者的预后。
To investigate the relationship between P53 gene mutation and pathological grade and clinical stage in bladder cancer, we analyzed the mutation of P53 gene in 46 cases of bladder cancer with silver staining by PCR-SSCP technique. The results showed that the mutation rate of P53 gene in bladder cancer was 30.4% , Poorly differentiated grade Ⅲ bladder cancer P53 gene mutation rate was significantly higher than Ⅰ, Ⅱ grade better differentiation. The incidence of P53 gene mutation in T3-4 bladder cancer with infiltration and metastasis was significantly higher than that in Tia-T1 superficial bladder cancer. Tip: P53 gene mutation is one of the biological markers of malignancy of bladder cancer, which can be used to evaluate the prognosis of patients.