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以乙酰乙酸乙酯为起始原料,经与原甲酸三乙酯缩合,与盐酸羟胺环合,再经酯水解和酰氯化得标题化合物,4步总收率在30%以上,产品含量在99%以上。
Ethyl acetoacetate as the starting material by condensation with triethyl orthoformate, hydroxylamine hydrochloride and cyclization, and then by ester hydrolysis and acid chloride to give the title compound, 4-step total yield of 30% or more, the product content of 99 %the above.