目的:研究第三代头孢菌素类抗菌药物药理作用和具体应用。方法:选择头孢噻肟、头孢曲松、头孢哌酮和头孢他啶四种常用第三代头孢菌素类抗菌药物,与前两代对比用药频度(DDDs),并分析药理作用及具体应用。结果:第三代DDDs值较第一代和复方制剂高;较第二代低,有显著差异(P<0.05),且具统计学意义。结论:第三代头孢菌素类抗菌药物应用基本合理,临床需加强药理分析及学习,确保药物安全、合理应用。 Objective: To study the pharmacological effects and specific application of the third generation cephalosporin antibiotics. Methods: Cefotaxime, ceftriaxone, cefoperazone and ceftazidime were selected as the third generation cephalosporin antimicrobial agents. The frequency of DDDs was compared with the previous two generations. The pharmacological effects and the specific application were also analyzed. Results: The third generation DDDs values ​​were higher than those of the first generation and compound preparations. Compared with the second generation, the DDDs were significantly different (P <0.05) and statistically significant. Conclusion: The application of the third generation cephalosporins antibacterial drugs is basically rational, need to strengthen pharmacological analysis and study in clinic, to ensure drug safety and rational application.