目的观察连续性血液滤过治疗脑创伤术后难治性急性脑膨出的临床效果。方法选取2014年3月—2016年9月咸阳市第一人民医院收治的脑创伤并发术后难治性急性脑膨出患者82例,采用随机数字表法分为对照组和观察组,每组41例。对照组患者给予常规治疗,观察组患者在常规治疗基础上行连续性血液滤过治疗。比较两组患者临床效果及预后。结果观察组患者临床效果优于对照组(P<0.05)。观察组患者中预后不良者所占比例低于对照组(P<0.05)。结论连续性血液滤过治疗脑创伤术后难治性急性脑膨出的临床效果确切,可有效改善患者预后。 Objective To observe the clinical effect of continuous hemofiltration in the treatment of refractory acute encephalocele after traumatic brain injury. Methods From March 2014 to September 2016, 82 patients with intracerebral hemorrhage complicated with postoperative intractable acute encephalocele admitted to the First People’s Hospital of Xianyang City were randomly divided into control group and observation group using random number table. Each group 41 cases. Patients in the control group were given routine treatment. Patients in the observation group were treated with continuous hemofiltration on the basis of routine treatment. The clinical effects and prognosis of the two groups were compared. Results The clinical effect of the observation group was better than that of the control group (P <0.05). The proportion of patients with poor prognosis in observation group was lower than that in control group (P <0.05). Conclusion Continuous hemofiltration in the treatment of intracranial trauma patients with intractable acute encephalocele clinical effect is exact, can effectively improve the prognosis of patients.