某些人类淋巴瘤如T细胞免疫母细胞瘤和霍奇金病,有时发生大量嗜酸性粒细胞浸润或血液中伴有广泛的嗜酸性粒细胞增多。作者曾用原位杂交方法证明,霍奇金病伴嗜酸性粒细胞浸润是由于Reedsternbery细胞产生的白细胞介素-5(IL-5)所致,因IL-5是一种能够促进嗜酸性粒细胞分化、增殖和趋化的细胞因子。本文应用高度敏感特异的多聚酶链反应(PCR)方法,旨在确定3例伴有嗜酸性 Some human lymphomas, such as T-cell immunoblastic tumors and Hodgkin’s disease, sometimes undergo extensive infiltration of eosinophils or extensive eosinophilia in the blood. The authors used in situ hybridization to demonstrate that Hodgkin’s disease with eosinophilic infiltration is due to interleukin-5 (IL-5) produced by Reedsternbery cells, which is an enzyme that promotes eosinophils. Cellular differentiation, proliferation and chemotaxis of cytokines. This article applies a highly sensitive and specific polymerase chain reaction (PCR) method designed to identify 3 cases with eosinophilic