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目的了解慢性阻塞性肺疾病(COPD)发作期与缓解期体内胶原、细胞因子变化与临床相关性,为临床治疗提供依据。方法将2002-03~2004-11河南省人民医院呼吸科40例COPD住院患者分为发作期、缓解期2组,并以健康老年人做对照,分别采用双抗夹心法、放射免疫分析法测定3组人群中胶原和细胞因子。结果COPD发作期与缓解期CⅠ、CⅢ、CⅣ均明显高于健康老年人(P<0.01),同时,发作期IL-1β、IL-8、TNF-α、IFN-γ明显高于健康对照组(P<0.01);缓解期IL-1β、TNF-α、IFN-γ也高于对照组(P<0.05)。结论细胞因子是导致COPD肺间质改变的主要机制之一。在常规治疗COPD的前提下,适当的抗炎治疗可能会延缓COPD的发展。
Objective To understand the changes of collagen and cytokines in the seizure and remission phases of chronic obstructive pulmonary disease (COPD) and its clinical correlation, so as to provide the basis for clinical treatment. Methods Forty patients with COPD admitted to Department of Respiratory, Henan Provincial People’s Hospital from March 2002 to November 2004 were divided into two groups according to their seizure phase and remission stage. The healthy elderly patients were treated with double antibody sandwich method and radioimmunoassay Collagen and cytokines in 3 groups of people. Results The levels of CⅠ, CⅢ and CⅣ in onset and remission of COPD were significantly higher than those in healthy elderly (P <0.01). Meanwhile, the levels of IL-1β, IL-8, TNF-α and IFN- (P <0.01). The levels of IL-1β, TNF-α and IFN-γ in remission group were also higher than those in control group (P <0.05). Conclusions Cytokines are one of the main mechanisms leading to pulmonary interstitial changes in COPD. In the conventional treatment of COPD under the premise of appropriate anti-inflammatory treatment may delay the development of COPD.