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来自不同微生物学环境的许多品系和种群的实验小鼠(Mus mulculus)中,都可观察到角膜混浊。这种混浊的特征,是角膜上皮和前角膜基质的急性和慢性炎性损害,包括角膜溃疡和糜烂、急性角膜炎、基质新生血管形成,以及基底膜区矿质化。饲养在屏障系统内的某些品系和种群的小鼠,具有角膜混浊的高发病率,如DBA/2(29.1％),C_3H(16.2％),和CF_1(16.2％),和BALB/C(10.0％)等。而有些品系和种群的发病率则低,如CD-1(4.3％)和C_(57)BL/6(4.1％)。无菌和悉生小鼠的角膜混浊发膜率很低(1.6％)。实验研究证实,每周两次清扫笼具,可使角膜混浊的发病率降到很低的水平。细菌性产物如氨,在实验小鼠自发性角膜混浊的发病机制上,
Corneal opacity was observed in Mus mulculus from many strains and populations of different microbiological environments. This hazy feature is both acute and chronic inflammatory damage of the corneal epithelium and the anterior corneal stroma, including corneal ulcers and erosions, acute keratitis, stromal neovascularization, and mineralization of the basement membrane area. Mice with certain strains and populations fed in the barrier system had high incidence of corneal opacities such as DBA / 2 (29.1%), C_3H (16.2%), and CF_1 (16.2%), and BALB / C 10.0%) and the like. However, the incidence of some strains and populations was low, such as CD-1 (4.3%) and C57BL / 6 (4.1%). The rate of corneal haze in germ-free and biologically-derived mice was low (1.6%). Experimental studies have confirmed that cage cleaning twice a week, the incidence of corneal opacity can be reduced to a very low level. Bacterial products such as ammonia, in the pathogenesis of spontaneous corneal opacity in experimental mice,