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磷脂酶D2(phospholipaseD2,PLD2)是一较为年轻的PLD家族成员,它可将磷脂酰胆碱裂解为磷脂酸及胆碱。它在细胞功能的诸多方面,如信号转导、膜组分交换、细胞骨架重排、细胞增殖及分化等过程中均有重要的作用。在病理状态下,PLD2可通过相应功能的变化参与某些疾病(如肿瘤、哮喘)的发生与发展。
Phospholipase D2 (PLD2), a younger member of the PLD family, cleaves phosphatidylcholine into phosphatidic acid and choline. It plays an important role in many aspects of cellular functions such as signal transduction, exchange of membrane components, rearrangement of cytoskeleton, cell proliferation and differentiation. In the pathological state, PLD2 can participate in the occurrence and development of certain diseases (such as tumor and asthma) through the corresponding functional changes.