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目的探讨肥胖症合并哮喘急性期儿童血液指标和炎性因子的变化。方法选取医院收治的肥胖症合并哮喘急性期儿童42例作为肥胖哮喘组,选取同期收治的儿童哮喘急性发作期患儿44例作为哮喘组,选取同期入院体检正常儿童40例作为正常组,对比三组血小板参数[血小板计数(PLT)、血小板分布宽度(PDW)、血小板糖膜蛋白CD62p]、凝血指标[抗凝血酶(AT)、纤维蛋白原(Fbg)、D二聚体(D-D)、凝血酶时间(TT)]及炎性因子[白细胞介素4(IL-4)、IL-6、IL-10)]水平。结果肥胖哮喘组的PLT、CD62p指标均显著高于哮喘组和正常组,组间差异有统计学意义(P<0.05),三组PDW指标差异无统计学意义(P>0.05);肥胖哮喘组的Fbg、D-D以及TT水平显著高于哮喘组和正常组,差异有统计学意义(P<0.05);而AT水平低于哮喘组和正常组,差异有统计学意义(P<0.05)。肥胖哮喘组炎性因子IL-4、IL-6水平显著高于哮喘组和正常组,差异有统计学意义(P<0.05)。结论肥胖症合并哮喘急性期儿童血液指标和炎性因子水平明显异常。
Objective To investigate the changes of blood indexes and inflammatory factors in children with obesity and acute asthma. Methods Forty-two children with obesity and acute asthma admitted to hospital were enrolled as obese asthma group. Forty-four children with acute exacerbation of childhood asthma were selected as asthma group. Forty normal children were enrolled in the same period as normal group, Platelet parameters such as platelet count (PLT), platelet distribution width (PDW), platelet glycoprotein CD62p, coagulation index (antithrombin (AT), fibrinogen (Fbg), D dimer Thrombin time (TT)] and inflammatory factors [interleukin 4 (IL-4), IL-6, IL-10)]. Results The levels of PLT and CD62p in obese asthmatic group were significantly higher than those in asthmatic group and normal group (P <0.05). There was no significant difference in PDW index between the three groups (P> 0.05) The levels of Fbg, DD and TT were significantly higher than those in asthma group and normal group (P <0.05). The levels of AT in asthma group and normal group were significantly lower than those in normal group (P <0.05). The levels of inflammatory cytokines IL-4 and IL-6 in obese asthma group were significantly higher than those in asthma group and normal group (P <0.05). Conclusion The levels of blood indexes and inflammatory cytokines in children with obesity and acute asthma are obviously abnormal.