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目的 本文对ALL患儿 13例用小剂量L -asp的用药方法 ,以求达到既能减低或避免副作用的发生 ,又能保证L -asp作用的效果 .方法 对在接受L -asp化疗的ALL患儿 5 9例 195疗程 ,出现L -asp相关副作用后改用小剂量 (常规剂量 1/ 10 )L -asp治疗的 13例 ,观察其副作用发生的情况 .结果 应用常规剂量者有 13例 34例次出现L-asp相关副作用 ,发生率为 17.4 % ,其中 2例因出血性胰腺炎死亡 .改用小剂量L -asp治疗者 13例 4 2个疗程 ,发生L -asp相关副作用者 2例次 ,发生率为 4 .8% ,显著低于应用常规剂量L -asp者 . 6例曾经发生过L -asp严重副作用的患儿在我科持续系统治疗 ,均未再次发生类似或其他L -asp副作用 ,CCR时间为 15 31± 14 0天 ,中位CCR时间为135 8天 .结论 对曾发生L -asp副作用的病例应用小剂量L -asp是安全有效的 .为预防L -asp相关副作用的发生 ,特别是已发生L -asp相关副作用的ALL患儿能继续应用L -asp治疗提供了科学的依据和可行的方法 .
Objective This article 13 cases of ALL children with low-dose L -asp medication in order to achieve both can reduce or avoid the occurrence of side effects, but also to ensure the effect of L -asp.Methods In patients receiving ALL chemotherapy A total of 59 children aged 195 were enrolled in this study. Thirteen of them were treated with low-dose L-asp (conventional dose 1/10) after L-asp-related side effects and the side effects were observed.Results Thirteen Case-related side effects of L-asp occurred, the incidence was 17.4%, of which 2 cases died of hemorrhagic pancreatitis. A small dose of L-asp treatment in 13 cases 42 cases of course, the occurrence of L -asp-related side effects in 2 cases Times, the incidence rate was 4.8%, significantly lower than the application of conventional dose of L-asp.6 cases had serious L -asp side effects in patients with continuous system treatment in our department, no recurrence of similar or other L - Asp side effects, CCR time was 15 31 ± 14 0 days, median CCR time was 135 8 days.Conclusion It is safe and effective to use low-dose L -asp in cases of side effects of L -asp.For the prevention of L-asp-related side effects Especially in children with ALL who have had L-asp-related side effects L -asp continue to apply the treatment to provide a scientific basis and feasible method.