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肝细胞癌(hepatocellular carcinoma,HCC)是我国最常见的恶性肿瘤之一,而HBV慢性感染是肝癌发生的主要原因.乙型肝炎病毒(HBV)中X基因编码的一种多功能蛋白(HBx),参与众多重要生物学过程的调控,并促进肝细胞癌的发生.早期研究表明,HBx在HCC发生过程中发挥重要的调控功能,但其确切分子机制尚未完全明确.近几年,HBx参与生物学过程的分子机制研究有了较快的进展.有趣的是,研究发现,HBx在不同的细胞系以及HBV感染的不同阶段发挥促抑凋亡的双重作用,HBx还参与细胞自噬的调控.此外,在HBx参与细胞增殖及肿瘤侵袭和转移等方面,也产生了一些新的认识.本文将从HBx对肝细胞凋亡、自噬和增殖的调控及其对肝癌细胞转移和侵袭的调控等方面,对HBx参与肝细胞癌发生发展调控机制做一综述.
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in our country, and chronic hepatitis B virus is the main cause of hepatocellular carcinoma.HBV, a multifunctional protein encoded by X gene in Hepatitis B virus, , Participate in the regulation of many important biological processes, and promote the occurrence of hepatocellular carcinoma.Early studies have shown that HBx plays an important regulatory role in the occurrence of HCC, but its exact molecular mechanism is not yet completely clear.In recent years, HBx involved in biological Interestingly, the study found that HBx plays a dual role in promoting apoptosis in different cell lines and in different stages of HBV infection, and HBx is also involved in the regulation of autophagy. In addition, some new understandings have also emerged in the aspects of HBx involved in cell proliferation and tumor invasion and metastasis, etc. In this paper, HBx is used to regulate hepatocyte apoptosis, autophagy and proliferation and its regulation on the metastasis and invasion of hepatoma cells In the aspect of HBx participating in the development and regulation of hepatocellular carcinoma, it is reviewed.