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目的：检测补体对免疫沉淀的抑制作用（ＩＰＣ），了解补体这一新功能在结核病中的情况，探讨特异性免疫复合物（ＩＣ）在结核病发病中的作用。方法：采用特异性抗原抗体检测结核病患者ＩＩＰＣ，同时测定患者血清ＣＩＣ及补体成分Ｃ３、Ｃ４水平。结果：ＣＩＣ水平在正常对照组为０．０９８±０．０３７，患者组中浸润型、纤维空洞型、粟粒型肺结核、肺外结核分别为０．２０１±０．０７４、０．１９９±０．０３６、０．１６２±０．０７７、０．１４４±０．０７０，与对照组相比均明显升高（Ｐ＜０．００１）；Ｉ－ＩＰＣ水平在正常对照组为０．４３±０．０８μｇ，患者组分别为０．１７±０．０４μｇ、０．２１±０．０７μｇ、０．２３±０．０９μｇ、０．３６±０．０９μｇ，均低于正常对照组（Ｐ＜０．０５～０．００１）；患者血清补体成分Ｃ３、Ｃ４亦有一定改变。结论：①结核病人血清中存在高水平的ＣＩＣ，其中主要为特异性ＩＣ；②患者Ｉ－ＩＰＣ补体新功能明显降低；③补体成分减少与ＩＰＣ的功能降低有一定关系
Objective: To detect the inhibitory effect of complement on immunoprecipitation (IPC), understand the new function of complement in tuberculosis and to explore the role of specific immune complex (IC) in the pathogenesis of tuberculosis. Methods: The specific antigen antibody was used to detect IIPC in patients with tuberculosis. The levels of serum CIC and complement components C3 and C4 were also determined. Results: The level of CIC was 0.098 ± 0.037 in normal control group. The infiltration type, fibrous cavity type, miliary tuberculosis and extrapulmonary tuberculosis in patients group were 0.201 ± 0.074 and 0.199 ± 0 respectively. 036,0.162 ± 0.077,0.144 ± 0.070, which were significantly higher than those in the control group (P <0.001). The level of I-IPC was 0.43 ± 0 in the normal control group. 08μg and 0.17 ± 0.04μg, 0.21 ± 0.07μg, 0.23 ± 0.09μg and 0.36 ± 0.09μg, respectively, which were lower than the normal control group (P <0.05 ~ 0.001); patients with serum complement components C3, C4 also have some changes. Conclusions: ①There is a high level of CIC in the serum of tuberculosis patients, which is mainly specific IC; ②The new function of I-IPC complement is significantly reduced; ③Decrease of complement component has something to do with the decline of IPC