目的：评价头孢西丁治疗细菌性感染的临床疗效和安全性。方法：７２例病人（男性３８例，女性３４例；年龄４２±ｓ１８ａ）采用头孢西丁３～６ｇ／ｄ×７～１４ｄ。结果：临床有效率为８６％，细菌清除率为８３％。药物的副作用少（发生率为３％）且轻微。药敏试验示大多数临床检出的革兰阴性杆菌和阳性球菌，除绿脓杆菌、不动杆菌、产气肠杆菌和肠球菌外，均对此药敏感，其敏感率与头孢呋辛相同而优于头孢唑林。结论：头孢西丁是治疗常见致病菌感染有效和安全的抗生素 Objective: To evaluate the clinical efficacy and safety of cefoxitin in the treatment of bacterial infections. Methods: 72 patients (38 males and 34 females; age 42 ± s18a) were treated with cefoxitin 3 ~ 6g / d × 7 ~ 14d. Results: The clinical effective rate was 86% and the bacterial clearance rate was 83%. Drugs have fewer side effects (3% incidence) and are mild. Susceptibility test showed that most of the clinical detection of gram-negative bacilli and positive cocci, in addition to Pseudomonas aeruginosa, Acinetobacter, Enterobacter aerogenes and enterococci, are sensitive to this drug, the sensitivity of the same with cefuroxime Better than cefazolin. Conclusion: Cefoxitin is an effective and safe antibiotic for the treatment of common pathogenic bacteria infections