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目的观察神经节苷脂治疗新生儿胆红素脑病的临床疗效。方法选取2014年2月—2015年2月桂林学院附属医院收治的新生儿胆红素脑病患儿56例,根据治疗方法不同分成对照组28例与观察组28例。对照组给予脑蛋白水解物治疗,观察组给予神经节苷脂治疗。比较两组患儿临床疗效及后遗症发生情况。结果观察组总有效率为85.7%(24/28),高于对照组的53.6%(15/28),差异有统计学意义(P<0.05);观察组后遗症发生率为39.3%(11/28),低于对照组的71.4%(20/28),差异有统计学意义(P<0.05)。结论神经节苷脂治疗新生儿胆红素脑病的临床疗效明显,可有效改善患儿的神经系统症状,减少后遗症的发生。
Objective To observe the clinical efficacy of ganglioside in the treatment of neonatal bilirubin encephalopathy. Methods 56 children with neonatal bilirubin encephalopathy admitted to Affiliated Hospital of Guilin University from February 2014 to February 2015 were divided into control group (n = 28) and observation group (n = 28) according to different treatment methods. The control group was given brain protein hydrolyzate treatment, and the observation group was given ganglioside treatment. The clinical efficacy and sequelae of the two groups were compared. Results The total effective rate in the observation group was 85.7% (24/28), which was higher than that in the control group (53.6%, 15/28) (P <0.05). The incidence of sequelae in the observation group was 39.3% 28), which was lower than 71.4% (20/28) of the control group, the difference was statistically significant (P <0.05). Conclusion Ganglioside treatment of neonatal bilirubin encephalopathy clinical curative effect is obvious, can effectively improve the children’s nervous system symptoms and reduce the occurrence of sequelae.