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目的研究脑梗塞患者血小板计数(PLT)、血小板平均体积(MPV)、血小板分布宽度(PDW)、平均血小板比积(PCT)变化及临床意义。方法检测100例脑梗塞患者和100例健康人PLT、MPV、PDW和PCT4项指标,并进行统计学分析。结果脑梗塞组与对照组血小板4项参数检测结果比较:脑梗塞组PLT较对照组显著降低(P<0.01);脑梗塞组MPV和PDW较对照组显著增高(P<0.01,P<0.05);脑梗塞组PCT较对照组降低,但差异无统计学意义(P>0.05)。脑梗塞组血小板4项参数随时间动态变化情况:脑梗塞后PLT呈逐渐下降趋势,3～4天时最低,以后又逐渐回升,但组间差异无统计学意义(P>0.05);脑梗塞后MPV、PDW和PCT均呈逐渐升高趋势,5～7天时达高峰,以后又逐渐降低,但组间差异均无统计学意义(P>0.05)。结论血小板平均体积增大是脑梗塞的独立危险指标,观察血小板平均体积的变化对脑梗塞的预防有指导意义。
Objective To study the changes of platelet count (PLT), platelet mean volume (MPV), platelet distribution width (PDW) and mean platelet volume (PCT) in patients with cerebral infarction and its clinical significance. Methods The indexes of PLT, MPV, PDW and PCT4 in 100 patients with cerebral infarction and 100 healthy people were detected and statistically analyzed. Results Compared with the control group, the PLT in cerebral infarction group was significantly lower than that in control group (P <0.01); MPV and PDW in cerebral infarction group were significantly higher than those in control group (P <0.01, P <0.05) PCT in cerebral infarction group was lower than that in control group, but the difference was not statistically significant (P> 0.05). In the infarction group, the four parameters of platelet dynamic changes with time: the PLT showed a gradual downward trend after cerebral infarction, the lowest at 3 ~ 4 days, and then gradually recovered, but there was no significant difference between the groups (P> 0.05); after cerebral infarction The MPV, PDW and PCT showed a gradual upward trend, reached a peak at 5-7 days and then gradually decreased. However, there was no significant difference between the two groups (P> 0.05). Conclusion The average platelet volume increase is an independent risk index of cerebral infarction. Observe that the change of average platelet volume has guiding significance for the prevention of cerebral infarction.