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目的：观察术前应用阿司匹林对腰椎手术患者出血的影响。方法收集行双节段腰椎手术的患者共106例，并将其分为3组：A组患者术前未服用过阿司匹林，B组患者服用阿司匹林，但在术前1周时停用，C组患者服用阿司匹林，但在术前1周并未停用。记录患者非甾体抗炎药物的服用情况，评估3组患者失血量的差异。结果不考虑其他非甾体抗炎药物的服用情况时，3组患者的术中、术后及总出血量比较差异无统计学意义（P＞0．05）。在未服用过其他非甾体抗炎药物的患者中，A组患者的出血量明显小于B组、C组患者，差异均有统计学意义（ P＜0．05）。在服用其他非甾体抗炎药的患者中，3组患者总出血量比较差异无统计学意义（P＞0．05）。结论阿司匹林会引起腰椎手术出血量的增加，而其他非甾体抗炎药物同样具有抗血小板作用，作为混杂因素，可对总出血量产生影响，手术医师应重视这些药物在术前的合理应用，以减少出血量。“,”Objective To observe the effect of aspirin on the blood losses of lumbar surgery .Methods A total of 106 patients who had undergone double segments of lumbar fusion surgery were selected for the study .They were divided into three groups .Group A didn′t take aspirin before the surgery .Group B and C had taken aspirin prior to the surgery ,but group B discontinued the medication one week before the operation ,and group C continued the use .In addition ,The use of non-steroid anti-inflammatory drug ( NSAIDs) in all patients was recorded ,and the amount of blood losses of the three groups were evalua-ted.Results When usage of other NSAIDs was not controlled ,the blood losses of intraoperative ,postoperative ,and total blood losses were found to have no statistical significance difference among the three groups .However ,when other NSAIDs usage was taken into account ,the amount of blood losses in group A was smaller than that of group B and C ,and the differences were sta-tistically significant(P0.05).Conclusion Aspirin can increase the risk of bleeding in patients un-dergoing lumbar surgery significantly ,and other NSAIDs have antiplatelet effect ,as confounding factors that may affect the total amount of bleeding .The surgeon should pay attention to the rational use of drugs in the preoperative ,to reduce the amount of bleeding .