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目的:通过对室间隔缺损合并的膜部瘤组织内细胞的增殖和存活能力进行组织学分析,了解膜部瘤这一特殊组织的病理学特性。方法:采用HE染色对假性和真性膜部瘤组织进行组织结构分析,采用Ki67和磷酸化Akt(pAkt)免疫组织化学染色对膜部瘤组织细胞的增殖和存活能力进行分析。结果:HE染色表明假性膜部瘤组织内细胞数量显著多于真性膜部瘤,但细胞外基质较少,结构比较疏松。Ki67染色结果提示假性膜部瘤细胞增殖能力强于真性膜部瘤,而磷酸化的Akt表达仅见于假性膜部瘤组织内部分细胞,真性膜部瘤组织无表达。结论:假性膜部瘤组织具有较强的细胞增殖和存活能力,是一种处于活跃状态的组织。
OBJECTIVE: To investigate the histopathological characteristics of membranous neoplasm, a specific tissue of the membranous neoplasms by histological analysis of the proliferation and viability of the membranous neoplasms. Methods: HE staining was used to analyze the histological structure of pseudomembranous neoplasms. Ki67 and phospho-Akt (pAkt) immunohistochemistry were used to analyze the proliferation and viability of membranous neoplasms. Results: Hematoxylin and eosin staining showed that the number of cells in the pseudomembranous tumor was significantly more than that in the true membranous tumor, but the extracellular matrix was less and the structure was loose. The results of Ki67 staining suggested that the proliferative ability of pseudomembranous tumor cells was stronger than that of true membranous tumor, while the expression of phosphorylated Akt was only found in some intraepithelial cells of pseudomembranous tumor, but not in true membranous tumor. Conclusion: Pseudomembranous tumor has a strong cell proliferation and survival ability, is an active tissue.