血吸虫病广泛分布于发展中国家,至今影响着2亿人的生活。已报道应用于曼氏血吸虫照射致弱尾蚴或重组抗原的数种啮齿类疫苗模型。尽管早在1962年用照射致弱的同种尾蚴免疫恒河猴成功地诱导出对日本血吸虫感染的保护力,但灵长类动物用作日本血吸虫疫苗模型的报道很少。本文作者描述了鼠猴(Saimiri sciurea)一种对日本血吸虫有用的灵长类疫苗模型。 Schistosomiasis is widely distributed in developing countries and so far affects the lives of 200 million people. Several rodent vaccine models have been reported for application to Schistosoma mansoni irradiated with cercariae or recombinant antigens. Although the immunization of Rhesus monkeys with irradiation-attenuated allo-cercariae successfully induced protection against Schistosoma japonicum infection as early as 1962, few reports have been reported on the use of primates as a vaccine against Schistosoma japonicum. The authors describe a Saimiri sciurea, a primate vaccine model useful for S. japonicum.