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对109例肺结核患者采用INH,RFD或RFP等联合抗房治疗60～90d后出现病变恶化,症状加重。X线胸片见肺部病灶扩大或增多。空洞、胸膜炎、痰菌阴转阳等反常现象。综合因素分析研究结果为：化疗方案不合理对例(19．2％)；免疫功能受损或低下19例(17．4％)；合并过敏性肺炎16例(14．6％)；暂时性恶化15例(13．7％)；耐药菌株感染13例(11．9％)；合并使用肾上腺皮质激素导致恶化12例(11．0％)；并用抗菌素或霉菌感染6例(5．5％)；结核合并矽肺4例(3．6％)；非典型抗酸菌感染3例(2．7％)。
109 cases of pulmonary tuberculosis patients with INH, RFD or RFP combined with anti-room therapy 60 ~ 90d after the deterioration of the disease, the symptoms worsened. X-ray chest to see enlarged or increased lung lesions. Empty, pleurisy, sputum negative yin and other anomalies. The results of comprehensive factor analysis were as follows: unreasonable chemotherapy regimen (19.2%); impaired or low immune function in 19 cases (17.4%); combined allergic pneumonia in 16 cases (14.6%); transient 15 (13.7%) were aggravated; 13 (11.9%) were infected with drug-resistant strains; 12 (11.0%) were associated with adrenal cortical hormone deterioration; 6 were infected with antibiotics or fungi %); Tuberculosis with silicosis in 4 cases (3.6%); atypical acid-fast bacilli in 3 cases (2.7%).