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目的探讨轻型地中海贫血妊娠患者血红蛋白(HGB)及铁蛋白(SF)水平变化对妊娠结局的影响。方法选取在医院定期产检并分娩的轻型地中海贫血妊娠患者38例作为地贫组,选取同期在医院定期产检并分娩的健康孕妇50例作为正常对照组,比较2组孕妇在不同妊娠时期HGB、SF水平及不良妊娠结局发生率。结果地贫组各个孕期HGB水平均低于正常对照组,整个孕期2组HGB均不同程度下降,且地贫组患者下降幅度大于正常对照组(P<0.01)。孕早期2组孕妇SF水平无明显差异(P>0.05);孕中期、孕晚期2组SF水平均不同程度下降,地贫组患者下降幅度大于正常对照组(P<0.01)。地贫组患者早产、剖宫产、产后出血、足月儿低体重、羊水异常发生率均高于正常对照组(P<0.05或P<0.01)。结论轻型地中海贫血妊娠患者HGB水平在整个孕期均不同程度下降,SF水平在孕中期、孕晚期不同程度下降,并可增加不良妊娠结局发生率。
Objective To investigate the effect of hemoglobin (HGB) and ferritin (SF) levels on pregnancy outcomes in patients with thalassemia of pregnancy. Methods Forty-eight patients with thalassemia of thalassemia were selected as the thalassemia group. Fifty healthy pregnant women who were regularly inspected and delivered in the hospital during the same period were selected as the normal control group. The levels of HGB, SF Level and adverse pregnancy outcomes. Results The levels of HGB in thalassemia group were lower than those in normal control group during the first trimester of pregnancy. The levels of HGB in the two groups during pregnancy decreased to different extents, and the declines in thalassemia groups were more than those in normal controls (P <0.01). SF level of pregnant women in the first trimester was no significant difference (P> 0.05). The levels of SF in the second trimester and the second trimester of pregnancy decreased to different extents. The decreasing rate in the thalassemia group was higher than that in the normal control group (P <0.01). The incidence of preterm birth, cesarean section, postpartum hemorrhage, full-term infants with low birth weight and amniotic fluid abnormality in thalassex isolated group were significantly higher than those in normal control group (P <0.05 or P <0.01). Conclusions HGB levels in patients with thalassemia of thalassemia decreased to varying degrees during the whole pregnancy. SF levels decreased in different stages of the second trimester and the third trimester of pregnancy, and increased the incidence of adverse pregnancy outcomes.