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目的:探讨序贯性血液净化对于急性重度有机磷农药中毒的临床治疗效果。方法:将100例急性重度有机磷农药中毒患者随机分为对照组和观察组,两组均先给予常规治疗,观察组在此基础上进行贯性血液灌流(HP)与连续性静脉一静脉血液滤过(CVVH),而对照组在常规治疗的基础上仅进行HP治疗。观察并比较两组患者的住院时间、昏迷时间、机械通气时间、血胆碱酯酶(ChE)活性恢复时间、治愈率及病死率。结果:观察组住院时间、昏迷时间、机械通气时间、ChE活性恢复时间与对照组比较明显减少(P<0.05),治愈率提高(P<0.05),病死率降低(P<0.05)。结论:HP序贯CVVH治疗对于急性重度有机磷农药中毒有显著的疗效。
Objective: To investigate the clinical effect of sequential blood purification on acute severe organophosphorus pesticide poisoning. Methods: One hundred patients with acute severe acute organophosphorus pesticide poisoning were randomly divided into control group and observation group. Both groups were given conventional treatment. On the basis of this, the observation group was divided into two groups: continuous hemodialysis (HP) and continuous venous-venous blood Filtration (CVVH), whereas the control group received only HP treatment on a routine treatment basis. The duration of hospitalization, coma, mechanical ventilation time, recovery time of ChE activity, cure rate and mortality were observed and compared between the two groups. Results: The hospitalization time, coma time, mechanical ventilation time and ChE activity recovery time in the observation group were significantly decreased compared with the control group (P <0.05). The cure rate increased (P <0.05) and mortality decreased (P <0.05). Conclusion: Sequential CVVH with HP has a significant effect on acute severe organophosphorus pesticide poisoning.