“化学前沿”从化学学科的角度报告了生物医药研究领域最新的理念和成就。报告中的信息和观点来源于汤森路透IntegritySM数据库。该数据库结合了生物、化学与药物学等学科的大量信息。本期报告分为有机合成路线展示、研究中的分子骨架、新化合物的作用机制、新研发管线等几个部分,从不同方面描述了对疗效和安全性更好的药物的筛选过程,并介绍了孤儿药的研究现状。 “Chemical frontier ” reported the latest ideas and achievements in the field of biomedical research from a chemical perspective. The information and opinions in this report are sourced from the Thomson Reuters IntegritySM database. The database combines a wealth of information on biology, chemistry and pharmacology. This report is divided into several sections such as organic synthesis route display, molecular framework under study, mechanism of action of new compounds, new R & D pipeline and so on, and describes screening and screening of drugs with better curative effect and safety from different aspects. The research status of orphan medicine.