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热休克蛋白（ＨＳＰＳ）是一种应激蛋白，广泛存在于人、动物、微生物和植物细胞内。ＨＳＰＳ同源保守性序列及其特定结构、功能与风湿性自身免疫、感染性自身免疫密切相关。ＨＳＰＳ参与蛋白跨膜前后折叠，作为分子伴侣促进ＨＳＰＳ自身整合及其终产物解离。实验证明，某些细菌、病毒、寄生虫感染后诱生的ＨＳＰＳ在风湿病发病及病情进展中具有重要作用。ＨＳＰＳ通过“共同表位”改变宿主自身免疫和自身耐受间平衡，机体产生异常免疫应答。类风湿性关节炎（ＲＡ）滑液存在ＨＳＰＳ性Ｔ细胞克隆活化，ＨＳＰ６５诱发ＲＡ活动，ＣＤ４-ＣＤ８-γδＴ细胞识别ＨＳＰ６５小片段多肽表位。
Heat shock protein (HSPS) is a stress protein that is widely found in humans, animals, microorganisms and plant cells. HSPS homologous conservative sequences and their specific structure, function and rheumatic autoimmune, infectious autoimmunity are closely related. HSPS participates in the transmembrane folding before and after, which acts as a chaperone to promote the self-integration of HSPS and the dissociation of its final product. Experiments show that some bacteria, viruses, parasites induced infection HSPS plays an important role in the pathogenesis and progression of rheumatism. HSPS through the “common epitope” to change the balance between host self-immunity and self tolerance, the body produces an abnormal immune response. RA rheumatoid arthritis (RA) synovial fluid exists HSPS T cell clones activation, HSP65-induced RA activity, CD4-CD8-γδT cells recognize HSP65 small fragment peptide epitopes.