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近来的一些报导已经指出细胞免疫机制能被自然发生的蛋白酶抑制剂所抑制,而且蛋白酶和蛋白酶抑制剂之间的平衡在免疫调节上起一定作用.两种主要的血清蛋白酶抑制剂是α_1-蛋白酶抑制剂(α_1-抗胰蛋白酶)和α2M.已知α2M存在于淋巴细胞和单核细胞表面而且由单核细胞和B细胞亚群产生.α2M在体外可抑制包括混合淋巴细胞反应(MLR)、有丝分裂原刺激和母细胞化的免疫反应.α2M可分成快的α2M和慢
Recent reports have indicated that cellular immune mechanisms can be inhibited by naturally occurring protease inhibitors and that the balance between protease and protease inhibitors plays a role in immune regulation.The two major serum protease inhibitors are alpha 1 -proteinase Inhibitors (α 1 -antitrypsin) and α 2 M. α 2 M is known to be present on the surface of lymphocytes and monocytes and is produced by monocytes and B cell subsets α 2 M inhibits, in vitro, including mixed lymphocyte reaction (MLR) Mitogen-stimulated and blastemal immune responses.α2M can be divided into fast α2M and slow