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多系统萎缩(Multiple system atrophy,MSA)是一组原因不明的进行性神经系统变性性疾病,目前国内外尚无统一分类及诊断标准。广义而言包括橄榄-脑桥-小脑萎缩(OPCA)、纹状体黑质变性(SND)、Shy-Drage综合征(SDS)、进行性核上性麻痹、巴金森痴呆、巴金森肌萎缩综合征及齿状核—红核—苍白球—路易核萎缩等,其临床表现相互重叠,又有区别。本文就临床相对常见;比较可能鉴别的MSA-OPCA,MSA-SND和MSA-SDS三者进行历史回顾及研究现状作一综述。
Multiple system atrophy (MSA) is a group of progressive neurodegenerative diseases of unknown origin. At present, there is no uniform classification and diagnostic criteria at home and abroad. In a broad sense, it includes olive-pons-cerebellar atrophy (OPCA), striatonigral degeneration (SND), Shy-Drage syndrome (SDS), progressive supranuclear palsy, Parkinson’s disease, Parkinson’s amyotrophy syndrome And dentate - red nucleus - globus pallidus - Louis nuclear atrophy, the clinical manifestations overlap, there are differences. This article reviews the clinical history of MSA-OPCA, MSA-SND and MSA-SDS, and summarizes the current status of the research.