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大家认为合成具有在环内能与大小和电子结构都适应的离子结合的官能团的闭环化合物,是制备高选择性有机分析试剂的途径之一。这条途径大自然已做了提示。在血红素、叶绿素、维生素B_(12)中就含有Fe(Ⅲ)、Mg(Ⅱ)、Co(Ⅲ)与环状结构的卟啉类络合物。肽、酯肽(depsipeptide)、苔酯酐(大环天然化合物)与碱金属和碱土金属元素很有选择性地形成稳定的络合物。缬氨霉素——环状酯肽类的抗生素——已被广泛用于钾离子离子选择性电极的制备。关于选择性一定是由环状结构决定的设想,是
It is believed that the synthesis of a closed-loop compound with functional groups capable of binding ions of ionizable size and electronic structure in the ring is one of the ways to prepare highly selective organic analytical reagents. Nature has made a hint of this route. In heme, chlorophyll and vitamin B_ (12), it contains porphyrin complexes of Fe (Ⅲ), Mg (Ⅱ), Co (Ⅲ) and cyclic structure. Peptides, depsipeptides, and taurates (macrocyclic natural compounds) form stable complexes with alkali and alkaline earth metals selectively. Valinomycin-cyclic ester peptide antibiotics have been widely used for the preparation of potassium ion selective electrodes. The idea that selectivity must be determined by the ring structure is