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目的比较来曲唑(LE)与克罗米酚(CC)促排卵治疗时对植入窗期子宫内膜整合素αVβ3和基质金属蛋白酶组织抑制因子-3(TIMP-3)表达的影响。方法收集2004年3~10月在本中心服用LE或CC促排卵治疗20例患者植入窗期子宫内膜(LE组9例,CC组11例),另取12例自然月经周期的相应时期内膜作为对照。通过免疫组织化学法测定整合素αVβ3和TIMP-3的表达强度。结果三组子宫内膜整合素αVβ3的表达强度无显著性差异;TIMP-3表达强度CC组高于LE和对照组。结论LE和CC都不影响植入窗期子宫内膜中整合素αVβ3的表达。CC使TIMP-3的表达信号明显加强。
Objective To compare the effects of letrozole (LE) and clomiphene citrate (CC) on the expression of integrin αVβ3 and TIMP-3 during the window implantation. Methods Twenty patients underwent LE or CC ovulation in our center from March to October 2004 were enrolled in the window of the endometrium (9 cases in LE group and 11 cases in CC group), and another 12 cases of natural menstrual cycle Intima served as controls. The intensity of integrin αVβ3 and TIMP-3 expression was determined by immunohistochemistry. Results There was no significant difference in the expression intensity of integrin αVβ3 in the three groups. The intensity of TIMP-3 expression in CC group was higher than that in LE group and control group. Conclusion Both LE and CC did not affect the expression of integrin αVβ3 in the endometrium during implantation window. CC significantly increased TIMP-3 expression.