论文部分内容阅读
目的用空白交联糊精微球作为载体制备交联糊精-碘微球,作为敷料用于慢性有渗出物伤口的治疗。方法使用吸附载药法,考察母液中乙醇含量、碘溶液浓度、微球吸水度对交联糊精-碘微球载药量和包封率的影响,以蒸馏水、生理盐水和模拟渗出液为释放介质,考察微球的体外释放,并对释放曲线进行方程拟合,预测释放机制。结果与结论在载药过程中,随着母液中乙醇含量的提高,载药量和包封率降低;乙醇含量一定的溶液中,碘浓度变大载药量提高,而包封率变化不大;吸水度高的微球载药量和包封率较吸水度低的微球高。交联糊精-碘微球体外释放符合Pep-pas方程(n=0.43),游离碘通过F ick扩散机制释放。在生理盐水和模拟渗出液中碘的释放进一步减缓,为交联糊精-碘微球作为敷料用于渗出性伤口的治疗时达到缓释作用奠定基础。
OBJECTIVE: To prepare crosslinked dextrin-iodine microspheres by using blank crosslinked dextrose microspheres as a carrier and as a dressing for the treatment of chronic exudate wounds. Methods The drug-loading method was used to investigate the effects of ethanol concentration, concentration of iodine solution and water absorption of microspheres on drug loading and entrapment efficiency of crosslinked dextrin-iodine microspheres. The effects of distilled water, saline and simulated exudate In order to release the medium, the in vitro release of microspheres was investigated, and the release curve was fitted by equation to predict the release mechanism. RESULTS AND CONCLUSION In the course of drug loading, with the increase of ethanol content in the mother liquor, the drug loading and entrapment efficiency decreased. In the solution with a certain amount of ethanol, the iodine concentration increased and the drug loading increased while the encapsulation efficiency did not change much ; Microspheres with high water absorbency and entrapment efficiency are higher than microspheres with low water absorption. The in vitro release of the cross-linked dextrin-iodine microspheres was in accordance with the Pep-pas equation (n = 0.43) and free iodine was released by the Fick diffusion mechanism. The release of iodine in saline and simulated exudate further slowed down, laying a foundation for the sustained release effect of the crosslinked dextrin-iodine microsphere as a dressing for the treatment of exudative wounds.