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目的:总结胆囊原发性腺鳞癌的临床病理特点及诊治经验。方法:回顾性分析1998年―2012年收治的4例胆囊腺鳞癌患者的临床资料。结果:4例患者中,3例行根治性手术,1例行姑息性手术;术后病理结果显示,癌组织中含有腺癌和鳞癌两种成分,CK8/18及CK5/64阳性;4例患者均于术后1年内死亡,中位生存期为180 d,均死于肿瘤复发或转移。结论:胆囊腺鳞癌非常罕见、恶性程度高、临床表现缺乏特异性,发现时分期已较晚;目前尚无有效的治疗方法,手术仍是目前主要的治疗手段,与胆囊腺癌相比总体预后较差。
Objective: To summarize the clinicopathological features and diagnosis and treatment of primary adenosquamous carcinoma of the gallbladder. Methods: The clinical data of 4 patients with gallbladder adenosquamous carcinoma admitted from 1998 to 2012 were analyzed retrospectively. Results: Among the 4 patients, 3 patients underwent radical surgery and 1 patient underwent palliative surgery. Postoperative pathological results showed that the cancer tissues contained both adenocarcinoma and squamous cell carcinoma, CK8 / 18 and CK5 / 64 were positive. 4 All patients died within 1 year after operation. The median survival time was 180 days, all of whom died of tumor recurrence or metastasis. Conclusions: Gallbladder adenosquamous carcinoma is very rare and has a high degree of malignancy. The clinical manifestations are not specific. It is found that the stage of staging is late. There is no effective treatment and surgery is still the main treatment at present. Compared with gallbladder adenocarcinoma, Poor prognosis.