论文部分内容阅读
目的:探讨抑郁症患者的注意转移情绪调节策略及其神经机制。方法:选取26名抑郁症患者(抑郁症组)及29名正常对照(对照组)参与研究，记录两组受试进行注意转移行为学范式的正确率及反应时，同时用Neuroscan 64导脑电仪检测两组受试者的N1、P3成分。运用SPSS 16.0对数据进行重复测量方差分析。结果:(1)在注意转移范式正确率上，组别主效应显著(n F＝11.626，n P＝0.001)，提示抑郁症组(0.82±0.01)显著低于对照组(0.89±0.01)(n P＝0.001)。在注意转移范式反应时上，组别主效应显著(n F＝16.55，n P<0.01)，提示抑郁症组[(1 460.82±41.86)ms]显著高于对照组[(1 226.31±39.63)ms](n P<0.01)。(2)在注意转移范式事件相关电位上，N1成分中组别主效应不显著(n F＝2.949，n P＝0.092)，任务与组别的交互作用显著(n F＝4.756，n P＝0.034)，提示抑郁症组在计算任务中诱发的N1波幅[(－3.699±0.441)μV]显著低于对照组[(－5.055±0.418)μV](n P＝0.030)；P3成分中组别主效应不显著(n F＝1.165，n P＝0.285)，任务与图片属性的交互作用显著(n F＝11.602，n P＝0.001)，提示情绪任务条件下负性图片诱发的P3波幅[(2.757±0.438)μV]显著高于中性图片[(1.963±0.460)μV](n P＝0.002)。n 结论:抑郁症患者存在情绪策略中的注意转移困难，且发生在早期阶段。“,”Objective:To investigate the attention deployment emotion regulation disorder and its neural mechanisms in major depressive disorder(MDD).Methods:Twenty-six MDD patients(MDD group) and twenty-nine healthy control individuals(control group) were enrolled in this study.The accuracy and reaction time were recorded in the attention deployment behavioral paradigm.Neuroscan 64 Brain Evoked Potentiometer was used to detect the N1 and P3 components of the above two groups of subjects.SPSS 16.0 software were used to analyze the data.Results:(1)In the accuracy of attention deployment paradigm, the group main effect was significant (n F=11.626, n P=0.001), indicating that the MDD group (0.82±0.01) was significantly lower than the control group(0.89±0.01)(n P=0.001). In the reaction time of attention deployment paradigm, the group main effect was significant(n F=16.55, n P<0.01), indicating that the MDD group (1 460.82±41.86)ms)was significantly higher than the control group(1 226.31±39.63)ms)(n P<0.01). (2)In the event-related potential of attention deployment paradigm, the group main effect of N1 was not significant (n F=2.949, n P=0.092), and the interaction between task and group was significant (n F=4.756, n P=0.034), indicating that the N1 amplitude induced by the MDD group in the calculation task(-3.699±0.441)μV) was significantly smaller than that of the control group (-5.055±0.418)μV)(n P=0.030). The group main effect of P3 was not significant (n F=1.165, n P=0.285), and the interaction between task and image attributes was significant (n F=11.602, n P=0.001), indicating that the P3 amplitude induced by negative images(2.757±0.438)μV) was significantly higher than that of neutral images (1.963±0.460)μV)(n P=0.002).n Conclusion:Patients with MDD have difficulty transferring attention in emotional strategies, and it occurs in the early stages.