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目的:探讨营养支持联合新辅助化疗对胃癌病人疗效、营养状况及机体组成变化的研究。方法:对88例以淋巴结转移为主的进展期胃癌采用卡培他滨+奥沙利铂方案化疗,并采用肠内营养支持,分析研究化疗疗效、手术情况、机体组成变化和化疗毒副反应情况。结果:88例中完全缓解(CR)4例(4.5%),部分缓解(PR)44例(50.0%),稳定(NC)32例(36.3%),进展(PD)8例(9.0%),近期客观有效率(CR+PR)为54.5%。平均体重、体质指数(BMI)和肌肉群(LBM)增加明显,并有统计学意义(P<0.05),其中体重增加>10%者16例,增加>5%者28例,维持不变者20例,下降者24例。行D2根治手术52例(59.1%),D2+根治手术24例(27.2%),姑息切除手术12例(13.6%),手术根治切除率达86.4%。结论:营养支持能改善进展期胃癌行新辅助化疗病人营养状况,提高生活质量,并顺利完成抗肿瘤治疗。
Objective: To investigate the nutritional support combined with neoadjuvant chemotherapy in patients with gastric cancer efficacy, nutritional status and body composition changes. Methods: Eighty-eight patients with advanced gastric cancer with lymph node metastasis were treated with capecitabine and oxaliplatin chemotherapy. The patients were enrolled in this study. Efficacy of chemotherapy, operation, body composition and chemotherapeutic toxicities Happening. Results: Of the 88 patients, 4 were complete remission (CR), 44 were partial remission (PR), 32 were stable (36.3%) and 8 (9.0% , The recent objective efficiency (CR + PR) was 54.5%. The average body weight, body mass index (BMI) and muscle mass (LBM) increased significantly, with statistical significance (P <0.05). Among them, 16 cases gained weight gain> 10%, 28 cases increased> 5% 20 cases, decreased in 24 cases. There were 52 cases (59.1%) who underwent D2 radical surgery, 24 cases (27.2%) underwent D2 radical surgery and 12 cases (13.6%) underwent palliative resection. The radical cystectomy rate was 86.4%. Conclusion: Nutritional support can improve nutritional status of neoadjuvant chemotherapy patients with advanced gastric cancer, improve quality of life and successfully complete anti-tumor therapy.